THE IMPORTANCE OF THE TIFFENEAU INDEX IN CHRONIC OBSTRUCTIVE PULMONARY DISEASES

Abstract

Chronic Obstructive Pulmonary Disease (COPD) poses a significant public health challenge in Uzbekistan, with environmental factors and smoking being primary contributors. The Tiffeneau index (FEV1/FVC ratio) remains a cornerstone in COPD diagnosis, but its regional application requires further evaluation.

Despite its global acceptance, limited research has explored the Tiffeneau index's diagnostic accuracy in diverse Uzbek populations, particularly concerning urban-rural disparities and environmental impacts.

A cross-sectional study was conducted involving 300 participants: 200 COPD patients diagnosed using GOLD criteria and 100 healthy controls. Spirometry was employed to calculate FEV1/FVC ratios, complemented by structured interviews on smoking, occupational exposure, and pollution. Comparative and multivariate analyses evaluated diagnostic accuracy and environmental influences.

COPD patients had significantly lower FEV1/FVC ratios compared to controls (mean = 0.62 vs. 0.84, p < 0.001). Urban areas showed higher COPD severity due to greater pollution exposure. The Tiffeneau index demonstrated high sensitivity (89%) and specificity (93%), affirming its utility in Uzbekistan’s clinical settings. Smoking history strongly correlated with disease severity (r = -0.68, p < 0.001).

The study validates the Tiffeneau index for COPD diagnosis and highlights the urgent need for targeted interventions, including smoking cessation programs and enhanced diagnostic access. Future research should address genetic predispositions, comorbidities, and longitudinal trends to refine COPD management strategies. These findings emphasize integrating evidence-based diagnostics and public health initiatives to mitigate the growing COPD burden in Uzbekistan.